Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs

Fuchsberger T, Clopath C, Jarzebowski P, Brzosko Z, Wang H, Paulsen O

eLife, 2022, https://doi.org/10.7554/eLife.81071

Contribution of behavioural variability to representational drift

Small, correlated changes in synaptic connectivity may facilitate rapid motor learning

Feulner B, Perich MG, Chowdhury RH, Miller LE, Gallego JA, Clopath C

Nature Communications, 2022, doi.org/10.1038/s41467-022-32646-w

Dopamine and serotonin interplay for valence-based spatial learning

Wert Carvajal C, Reneaux M, Tchumatchenko T, Clopath C

Cell Reports, 2022, https://doi.org/10.1016/j.celrep.2022.110645

Maslow's Hammer in Catastrophic Forgetting: Node Re-Use vs. Node Activation

A tale of two transmitters: serotonin and histamine as in vivo biomarkers of chronic stress in mice

Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications

Neuronal activity in sensory cortex predicts the specificity of learning in mice

Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation


Learning and attention increase visual response selectivity through distinct mechanisms

Spectral Normalisation for Deep Reinforcement Learning: An Optimisation Perspective

Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits

Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks

Free recall scaling laws and short-term memory effects in a latching attractor network

Local circuit amplification of spatial selectivity in the hippocampus

Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity

Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function

The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning

Ang GWY, Tang CS, Hay YA, Zannone S, Paulsen O, Clopath C

Plos Comp. Biol., 2021, doi/10.1371/journal.pcbi.1009017

Learning compositional sequences with multiple time scales through a hierarchical network of spiking neurons

Visualizing a joint future of neuroscience and neuromorphic engineering

Neural manifold under plasticity in a goal driven learning behaviour


Inhibitory stabilization and cortical computation

Theory of neuronal perturbome in cortical networks

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Udakis M, Pedrosa V, Chamberlain S, Clopath C, Mellor J

Nature Communications, 2020, doi:10.1038/s41467-020-18074-8

The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields

AI for social good: unlocking the opportunity for positive impact

Population coupling predicts the plasticity of stimulus responses in cortical circuits

Patterned perturbation of inhibition can reveal the dynamical structure of neural processing

Learning spatiotemporal signals using a recurrent spiking network that discretizes time


Deep Reinforcement Learning for Subpixel Neural Tracking

Dai T, Dubois M, Arulkamaran K, Campbell J, Bass C, Billot B, Uslu F, De Paola V, Clopath C, Bharath A

Proceedings of The 2nd International Conference on Medical Imaging with Deep Learning, 2019, PMLR 102:130-150

Image Synthesis with a Convolutional Capsule Generative Adversarial Network

Bass C, Dai T, Billot B, Arulkamaran K, Creswell A, Clopath C, De Paola V, Bharath A

Proceedings of The 2nd International Conference on Medical Imaging with Deep Learning, 2019, PMLR 102:39-62

Unifying Long-Term Plasticity Rules for Excitatory Synapses by Modeling Dendrites of Cortical Pyramidal Neurons

Ebner C, Clopath C, Jedlicka P, Cuntz H

Cell Reports, 2019, doi:10.1016/j.celrep.2019.11.068

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

Knöpfel T, Sweeney Y, Radulescu C, Zabouri N, Doostdar N, Clopath C, Barnes S

Nature Communications, 2019, doi:10.1038/s41467-019-13607-2

Inhibitory microcircuits for top-down plasticity of sensory representations

A deep learning framework for neuroscience

A diversity of interneurons and Hebbian plasticity facilitate rapid compressible learning in the hippocampus

Policy Consolidation for Continual Reinforcement Learning

Synaptic plasticity onto inhibitory neurons as a mechanism for ocular dominance plasticity


Cerebellar learning using perturbations

Bouvier G, Aljadeff J, Clopath C, Bimbard C, Ranft J, Blot A, Nadal J-P, Brunel N, Hakim V, Barbour B

eLife, 2018, doi:10.7554/eLife.31599

Continual Reinforcement Learning with Complex Synapses

Chaos in homeostatically regulated neural systems

Nicola W, Hellyer PJ, Campbell SA , Clopath C

Chaos, 2018, doi:10.1063/1.5026489

Acetylcholine-modulated plasticity in reward-driven navigation: a computational study

Zannone S, Brzosko Z, Paulsen O, Clopath C

Scientific Reports, 2018, doi:10.1038/s41598-018-27393-2

ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity

Sollini J, Chapuis G, Clopath C*, Chadderton P*

Nature Communications, 2018, doi:10.1038/s41467-018-04548-3

Gap junction plasticity as a mechanism to regulate network-wide oscillations

Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo

Gonzalez-Rueda A, Pedrosa V, Feord RC, Clopath C, Paulsen O

Neuron, 2018, doi:10.1016/j.neuron.2018.01.047

Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo


Supervised learning in spiking neural networks with FORCE training

Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level

Modelling plasticity in dendrites: from single cells to networks

From homeostasis to behavior: Balanced activity in an exploration of embodied dynamic environmental-neural interaction.

Hellyer P, Clopath C, Kehagia A, Turkheimer F, Leech R

PLoS Comp. Biol., 2017, doi:10.1371/journal.pcbi.1005721

Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation.

Brzosko Z*, Zannone S*, Schultz W, Clopath C#, Paulsen O#

eLife, 2017, doi:10.7554/eLife.27756

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss

Samuel J. Barnes, Eleonora Franzoni, R. Irene Jacobsen, Ferenc Erdelyi, Gabor Szabo, Claudia Clopath, Georg B. Keller, Tara Keck

Neuron, 2017, doi:10.1016/j.neuron.2017.09.052

Sparse synaptic connectivity is required for decorrelation and pattern separation in feedforward networks

Detection of axonal synapses in 3D two-photon images

Bass C, Helkkula P, De Paola V, Clopath C, Bharath A

PLoS ONE, 2017, https://doi.org/10.1371/journal.pone.0183309

Overcoming catastrophic forgetting in neural networks.

Kirkpatrick J, Pascanu R, Rabinowitz N, Veness J, Desjardins G, Rusu AA, Milan K, Quan J, Ramalho T, Grabska-Barwinska A, Hassabis D, Clopath C, Kumaran D, and Hadsell R

Proceedings of the National Academy of Sciences, 2017

Variance and Invariance of Neuronal Long-term Representations.

The Role of Neuromodulators in Cortical Plasticity. A Computational Perspective.


Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.

Badura A*, Clopath C*, Schonewille , de Zeuuw CI

Scientific Reports, 2016

Emergent spatial synaptic structure from diffusive plasticity

Local inhibitory plasticity tunes macroscopic brain dynamics and allows the emergence of functional brain networks.

PJ Hellyer, B Jachs, C Clopath*, R Leech*

NeuroImage 124, 85-95, 2016


Emergence of Functional Specificity in Balanced Networks with Synaptic Plasticity.

Processing of Feature Selectivity in Cortical Networks with Specific Connectivity.


Oscillations emerging from noise-driven steady state in networks with electrical synapses and subthreshold resonance.

A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.

Clopath C*, Badura A*, de Zeuuw CI and Brunel N

Journal of Neuroscience, 2014, 34(21):7203-7215


The emergence of functional microcircuits in visual cortex.

Ko H*, Cossell L*, Baragli C, Antolik J, Clopath C, Hofer SB and Mrsic-Flogel TD

Nature, 2013, 496, 96-100

Optimal properties of analog perceptrons with excitatory weights.


Storage of correlated patterns in standard and bistable Purkinje cell models.


Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks.

Vogels TP*, Sprekeler H*, Zenke F, Clopath C and Gerstner W

Science, 2011, 334(6062)1569-1573

A triplet spike-timing-dependent plasticity model generalizes the Bienenstock-Cooper-Munro rule to higher-order spatiotemporal correlations.

Gjorgjieva J, Clopath C, Audet J and Pfister J-P

PNAS, 2011, 108 (48), 19097-19098

Synaptic consolidation: an approach to long-term learning.


Voltage and Spike Timing interact in STDP - a Unified Model.

Connectivity reflects coding: A model of voltage-based spike-timing-dependent-plasticity with homeostasis.

Clopath C, Buesing L, Vasilaki E and Gerstner W

Nature Neuroscience, 2010, 13, 344-352


Tag-Trigger-Consolidation: A model of early and late long-term potentation and depression.

Clopath C, Ziegler L, Vasilaki E, Buesing L and Gerstner W

PLoS Comp. Biol., 2008, 4, e1000248

An online Hebbian learning rule that performs Independent Component Analysis.

Firing Patterns in the Adaptive Exponential Integrate-and-Fire.

Naud R, Marcille N, Clopath C and Gerstner W

Biological Cybernetics, 2008, 98:459-478


Predicting Neuronal Activity with Simple Models of the Threshold Type: Adaptive Exponential Integrate-and-Fire Model with Two Compartments.

Clopath C, Jolivet R, Rauch A, Luescher H-R and Gerstner W

Neurocomputing, 2007, 70, 1668 - 1673